When To Test Pregnancy After Duphaston?

What happens if you don’t get your period after taking duphaston

Patient’s Query Hi doctor, I am 30 years old. I have missed my period for eight days now. On my 24th day of the menstrual cycle, I started using Duphaston once daily and finished the dose yesterday. Usually, my menstrual cycle comes between 26 to 28 days.

This month, I got cramps but nothing came out. Could this be a side effect of Duphaston? Answered by Dr. Sravanthi Nuthalapati # Hi, Welcome to icliniq.com. I want to know the reason for taking Duphaston ( Dydrogesterone ). If you are planning for pregnancy, then it is advisable to check pregnancy once using a urine pregnancy test at home.

If it is negative, then you can wait for two weeks to get your periods as you have finished your course of Duphaston yesterday. It takes a maximum of two weeks to have withdrawal bleeding once the Duphaston is stopped. If you are pregnant, then you will not get your periods even after two weeks.

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• Consult a doctor now! Related Questions: Does Duphaston delay periods? If you are planning for pregnancy, then it is advisable to check pregnancy once using a urine pregnancy test at home,
• Read full Why am I having spotting after taking Femosten Conti?,

the query. I can understand your concern. Femoston conti contains Dydrogesterone and Estradiol hemihydrate means combination of progesterone and estrogen to treat the symptoms of menopause. Usually prolonged use of hormone replacement therapy is n. Read full Is it advisable to take Duphaston during pregnancy?,

• Gone through the case summary.
• As she has had PCOD, in such patient, there is a deficiency of pregnancy hormone Progesterone.
• So we have to give from outside to support pregnancies.
• There is a history of two miscarriages.
• Can you tell me where did.
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How long does duphaston stay in the body

Each film-coated tablet contains 10 mg dydrogesterone. The score line is only to facilitate breaking for ease of swallowing and not to divide into equal doses. Excipient(s) with known effect: Each tablet contains 111.1 mg Lactose monohydrate. Excipients/Inactive Ingredients: Core: Lactose monohydrate, Hypromellose, Maize starch, Colloidal anhydrous silica, Magnesium stearate.

Film-Coating: Hypromellose, Macrogol 400, Titanium dioxide (E171). Pharmacotherapeutic group: Genito-urinary system and sex hormones. ATC code: G03DB01. Pharmacology: Pharmacodynamics: Mechanism of action: Dydrogesterone is an orally active progestogen which produces a complete secretory endometrium in an estrogen-primed uterus thereby providing protection against the increased risk for endometrium hyperplasia and/or carcinogenesis induced by estrogens.

It is indicated in all cases of endogenous progesterone deficiency. Dydrogesterone has no estrogenic, no androgenic, no thermogenic, no anabolic and no corticoid activity. Adolescent population: Limited clinical trial data indicate that dydrogesterone is efficacious in relieving symptoms of dysmenorrhoea, premenstrual syndrome, dysfunctional uterine bleeding and irregular cycles in the population of patients younger than 18 years of age in a similar manner as in the adult population.

Clinical efficacy and safety: Lotus I and Lotus II climical study(s) confirmed the following: A Double-Blind, Double-Dummy, Randomized, Two-arm, Multicentre Study Comparing the Efficacy, Safety, and Tolerability of Oral Dydrogesterone 30 mg daily versus Intravaginal Micronized Progesterone Capsules 600 mg daily for Luteal Support in In-Vitro Fertilization (LOTUS I).

A randomized, Open-label, Two-arm, Multicenter Study Comparing the Efficacy, Safety and Tolerability of Oral Dydrogesterone 30 mg daily versus Crinone 8% intravaginal progesterone gel 90 mg daily for Luteal Support in In Vitro Fertilization (LOTUS II).

• The primary objective of non-inferiority of oral dydrogesterone compared to intravaginal micronized progesterone in terms of the presence of fetal heartbeats at 12 weeks’ gestation (week 10) was achieved.
• In the studied patient population, pregnancy rates at 12 weeks’ gestation (week 10) were 37.6% and 33.1% (LOTUS I) and 36.7% and 34.7% (LOTUS II).

The difference in the pregnancy rate between the two groups was 4.7 (95% CI, -1.2; 10.6) (LOTUS I) and 2.0 (95% CI, -0.4; 0.8) (LOTUS II). Within the safety sample of 1,029 subjects (LOTUS I) and 1030 subjects (LOTUS II) with at least one dose of study medication administered, the incidence of the most frequently reported TEAEs was similar between the two treatment groups.

Due to the nature of the indication and the studied patient population, a number of early abortions and miscarriages can be expected. Especially until 12 weeks’ gestation (pregnancy week 10), the expected pregnancy rate is about 35%. The safety profile observed both LOTUS studies is as expected taking into account the well-established safety profile of dydrogesterone and the treatment population and indication.

Pharmacokinetics: Absorption: Following oral administration, dydrogesterone is rapidly absorbed with a Tmax between 0.5 and 2.5 hours. The absolute bioavailability of dydrogesterone (oral 20 mg dose versus 7.8 mg intravenous infusion) is 28 %. The following table provides pharmacokinetic parameters of dydrogesterone (D) and 20α- dihydrodydrogesterone (DHD) after single dose administration of 10 mg dydrogesterone: See Table 1: Click on icon to see table/diagram/image After intravenous administration of dydrogesterone the steady-state volume of distribution is approximately 1400 L. Dydrogesterone and DHD are more than 90% bound to plasma proteins. Metabolism: Following oral administration, dydrogesterone is rapidly metabolized to DHD. The levels of the main active metabolite DHD peak about 1.5 hours postdose. The plasma levels of DHD are substantially higher as compared to the parent drug. The AUC and Cmax ratios of DHD to dydrogesterone are in the order of 40 and 25, respectively. Mean terminal half lives of dydrogesterone and DHD vary between 5 to 7 and 14 to 17 hours, respectively. A common feature of all metabolites characterised is the retention of the 4,6 diene-3-one configuration of the parent compound and the absence of 17α-hydroxylation. This explains the lack of estrogenic and androgenic effects of dydrogesterone. Elimination: After oral administration of labelled dydrogesterone, on average 63% of the dose is excreted into the urine. Total plasma clearance is 6.4 L/min. Within 72 hours excretion is complete. DHD is present in the urine predominantly as the glucuronic acid conjugate. Dose and time dependencies: The single and multiple dose pharmacokinetics are linear in the oral dose range 2.5 to 10 mg. Comparison of the single and multiple dose kinetics shows that the pharmacokinetics of dydrogesterone and DHD are not changed as a result of repeated dosing. Steady state was reached after 3 days of treatment. Toxicology: Preclinical safety data: Non-clinical data obtained from conventional studies on single and repeated dose toxicity, genotoxicity and carcinogenic potential reveal no special hazard for humans. Reproduction toxicity studies in rats have shown an increased incidence of prominent nipples (between day 11 and day 19 of age) and of hypospadias in the male offspring at high dosages not comparable to human exposure. The actual risk of hypospadias in humans cannot be determined in animal studies due to major species differences in metabolism between rats and humans (see Use in Pregnancy & Lactation). Limited animal safety data suggest that dydrogesterone has prolongating effects on parturition, which is consistent with its progestogenic activity. Progesterone deficiencies: Treatment of dysmenorrhoea. Treatment of endometriosis. Treatment of secondary amenorrhoea. Treatment of irregular cycles. Treatment of dysfunctional uterine bleeding. Treatment of pre-menstrual syndrome. Treatment of threatened abortion, associated with proven progesterone deficiency. Treatment of habitual abortion, associated with proven progesterone deficiency. Treatment of infertility due to luteal insufficiency. Luteal support as part of an Assisted Reproductive Technology (ART) treatment. Hormone replacement therapy: To counteract the effects of unopposed estrogen on the endometrium in hormone replacement therapy for women with disorders due to the natural or surgical induced menopause with an intact uterus. Always take Duphaston exactly as the doctor has prescribed. If there are any questions, contact the doctor or pharmacist. If the patient forgets to take the tablet(s), do not take a double dose to compensate for it. If the patient requires further information, please ask the doctor or pharmacist for advice. For hormone replacement therapy: In combination with continuous oestrogen therapy, take one tablet daily for 14 consecutive days of a 28 day cycle. In combination with cyclical oestrogen therapy, take one tablet daily during the last 12 to 14 days of oestrogen therapy. For doctors: If endometrial biopsies or ultrasound reveal inadequate progestational response, 20 mg dydrogesterone should be prescribed. If the patient is not sure what type of oestrogen therapy, talk to the doctor before taking Duphaston. Posology for specific indications: Dysmenorrhoea (painful menstruation): Take one tablet twice daily from day 5 to day 25 of the cycle. Endometriosis (abnormal growth of uterine tissues outside the uterus): Take one tablet two or three times daily from day 5 to day 25 of the cycle or continuously (as prescribed by the doctor). Dysfunctional bleeding (to stop bleeding): Take one tablet twice daily for five to seven days. Dysfunctional bleeding (to prevent bleeding): Take one tablet twice daily from day 11 to day 25 of the cycle. Amenorrhoea (cessation of menstruation): The doctor should prescribe an oestrogen along with Duphaston. Then take the oestrogen once daily from day 1 to day 25 of the cycle, together with one tablet of dydrogesterone twice daily from day 11 to day 25 of the cycle. Premenstrual syndrome: Take one tablet twice daily from day 11 to day 25 of the cycle. Irregular cycles: Take one tablet twice daily from day 11 to day 25 of the cycle. Threatened abortion: Take four tablets at once, then one tablet every eight hours until symptoms abate. Habitual abortion: Take one tablet twice daily until the twentieth week of pregnancy. Infertility due to luteal (yellow body) insufficiency: Take one tablet daily from day 14 to 25 of the cycle. Continue the treatment for at least six consecutive cycles. In addition, it is advisable to continue treatment for the first few months of pregnancy as described under “Habitual abortion”. If the patient is uncertain about how long to continue the treatment, talk to the doctor. Luteal support as part of an Assisted Reproductive Technology (ART) treatment: Take one tablet three times daily (30mg daily) starting at the day of oocyte retrieval and continuing for 10 weeks if pregnancy is confirmed. Duphaston is not recommended for use in children below age 18 due to insufficient data on safety and efficacy. Limited data are available with regard to overdose in humans. Dydrogesterone was well tolerated after oral dosing (maximum daily dose taken to date in humans 360mg). There are no specific antidotes and treatment should be symptomatic. This information is also applicable for overdose in children. Known hypersensitivity to the active substance or to any of the excipients. Known or suspected progestogen dependent neoplasms (e.g. meningioma). Undiagnosed vaginal bleeding. Contraindications which are related to the use of estrogen when Duphaston is used in combination with estrogen (see also the contraindication in the product information of the estrogen preparation). Treatment for luteal support as part of an Assisted Reproductive Technology (ART) treatment should be discontinued upon diagnosis of abortion or miscarriage. Before initiating dydrogesterone treatment for abnormal bleeding the etiology for the bleeding should be clarified. Breakthrough bleeding and spotting may occur during the first months of treatment. If breakthrough bleeding or spotting appears after some time on therapy, or continues after treatment has been discontinued, the reason should be investigated, which may include endometrial biopsy to exclude endometrial malignancy. Conditions which need supervision: If any of the following conditions are present, have occurred previously, and/or have been aggravated during pregnancy or previous hormone treatment, the patient should be closely supervised. It should be taken into account that these conditions may recur or be aggravated during treatment with dydrogesterone and ceasing the treatment should be considered: Porphyria; Depression; Abnormal liver function values by acute and chronic liver disease. Other conditions: Patients with rare hereditary problems of galactose intolerance, Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine. The following precautions apply when using dydrogesterone in combination with estrogens for hormone replacement therapy (HRT): See precautions in the product information of the estrogen preparation. For the treatment of postmenopausal symptoms, HRT should only be initiated for symptoms that adversely affect quality of life. In all cases, a careful appraisal of the risks and benefits should be undertaken at least annually and HRT should only be continued as long as the benefit outweighs the risk. Evidence regarding the risks associated with HRT in the treatment of premature menopause is limited. Due to the low level of absolute risk in younger women, however, the balance of benefits and risks for these women may be more favorable than in older women. Medical examination/follow-up: Before initiating or reinstituting HRT, a complete personal and family medical history should be taken. Physical (including pelvic and breast) examination should be guided by this and by the contraindications and warnings for use. During treatment, periodic check-ups are recommended of a frequency and nature adapted to the individual woman. Women should be advised what changes in their breasts should be reported to their doctor or nurse (see ‘Breast cancer’ as follows). Investigations, including appropriate imaging tools, e.g., mammography, should be carried out in accordance with currently accepted screening practices, modified to the clinical needs of the individual. Endometrial hyperplasia and carcinoma: In women with an intact uterus the risk of endometrial hyperplasia and carcinoma is increased when estrogens are administered alone for prolonged periods. The addition of a progestogen such as dydrogesterone cyclically for at least 12 days per month/28 day cycle or continuous combined estrogen-progestogen therapy in nonhysterectomized women can prevent the excess risk associated with estrogen-only HRT. Breast cancer: The overall evidence suggests an increased risk of breast cancer in women taking combined estrogen-progestogen and possibly also estrogen-only HRT, that is dependent on the duration of taking HRT. Combined estrogen-progestogen therapy: The randomized placebo-controlled trial, Women’s Health Initiative study (WHI), and epidemiological studies are consistent in finding an increased risk of breast cancer in women taking combined estrogen-progestogen for HRT that becomes apparent after about 3 years. The excess risk becomes apparent within a few years of use but returns to baseline within a few (at most five) years after stopping treatment. HRT, especially estrogen-progestogen combined treatment, increases the density of mammographic images which may adversely affect the radiological detection of breast cancer. Ovarian cancer: Ovarian cancer is much rarer than breast cancer. Epidemiological evidence from a large meta-analysis suggests a slightly increased risk in women taking oestrogen-only or combined oestrogen-progestogen HRT, which becomes apparent within 5 years of use and diminishes over time after stopping. Some other studies including the WHI trial suggest that use of combined HRTs may be associated a similar, or slightly smaller, risk. Venous thrombo-embolism: HRT is associated with a 1.3-3 fold risk of developing venous thromboembolism (VTE), i.e.deep vein thrombosis or pulmonary embolism. The occurrence of such an event is more likely in the first year of HRT than later. Patients with known thrombophilic states have an increased risk of VTE and HRT may add to this risk. HRT is therefore contraindicated in these patients. Generally recognized risk factors for VTE include, use of estrogens, older age, major surgery, prolonged immobilization, obesity (BMI > 30 kg/m 2 ), pregnancy/postpartum period, systemic lupus erythematosus (SLE), and cancer. There is no consensus about the possible role of varicose veins in VTE. As in all postoperative patients, prophylactic measures need be considered to prevent VTE following surgery. If prolonged immobilization is to follow elective surgery temporarily stopping HRT 4 to 6 weeks earlier is recommended. Treatment should not be restarted until the woman is completely mobilized. In women with no personal history of VTE but with a first degree relative with a history of thrombosis at young age, screening may be offered after careful counseling regarding its limitations (only a proportion of thrombophilic defects are identified by screening). If a thrombophilic defect is identified which segregates with thrombosis in family members or if the defect is ‘severe’ (e.g., antithrombin, protein S, or protein C deficiencies or a combination of defects) HRT is contraindicated. Women already on chronic anticoagulant treatment require careful consideration of the benefit risk of use of HRT. If VTE develops after initiating therapy, the drug should be discontinued. Patients should be told to contact their doctors immediately when they are aware of a potential thromboembolic symptom (e.g., painful swelling of a leg, sudden pain in the chest, dyspnea). Coronary artery disease (CAD): There is no evidence from randomized controlled trials of protection against myocardial infarction in women with or without existing CAD who received combined estrogen-progestogen or estrogen-only HRT. Combined estrogen-progestogen therapy: The relative risk of CAD during use of combined estrogen-progestogen HRT is slightly increased. As the baseline absolute risk of CAD is strongly dependent on age, the number of extra cases of CAD due to estrogen-progestogen use is very low in healthy women close to menopause, but will rise with more advanced age. Ischemic stroke: Combined estrogen-progestogen and estrogen-only therapy are associated with an up to 1.5-fold increase in risk of ischemic stroke. The relative risk does not change with age or time since menopause. However, as the baseline risk of stroke is strongly age-dependent, the overall risk of stroke in women who use HRT will increase with age. Effects on ability to drive and use machines: Dydrogesterone has minor influence on the ability to drive and use machines. Infrequently, dydrogesterone may cause mild somnolence and/or dizziness, especially within the first few hours after intake. Therefore, care should be taken when driving or using machines. Pregnancy: It is estimated that more than 10 million pregnancies have been exposed to dydrogesterone. So far there were no indications of a harmful effect of dydrogesterone use during pregnancy. Some progestogens have been reported in the literature to be associated with an increased risk of hypospadias. However due to confounding factors during pregnancy, no definitive conclusion can be drawn regarding the contribution of progestogens to hypospadias. Clinical studies, where a limited number of women were treated with dydrogesterone early in pregnancy, have not shown any increase in risk. No other epidemiological data are hitherto available. Effects in non-clinical embryo-fetal and post-natal development studies were in line with the pharmacological profile. Untoward effects occurred only at exposures which exceeded the maximum human exposure considerably, indicating little relevance to clinical use (see Pharmacology: Toxicology: Preclinical safety data under Actions). Dydrogesterone can be used during pregnancy if clearly indicated. Breastfeeding: No data exist on excretion of dydrogesterone in mother’s milk. Experience with other progestogens indicates that progestogens and the metabolites pass to mother’s milk in small quantities. Whether there is a risk to the child is not known. Therefore, dydrogesterone should not be used during the lactation period. Fertility: There is no evidence that dydrogesterone decreases fertility at therapeutic dose. The most commonly reported adverse drug reactions of patients treated with dydrogesterone in clinical trials of indications without estrogen treatment are vaginal haemorrhage, migraines/headache, nausea, vomiting, abdominal pain, menstrual disorders and breast pain/tenderness. The following undesirable effects have been observed with the frequencies indicated as follows during clinical trials using dydrogesterone (n=3483) in indications without estrogen treatment, in two company sponsored interventional clinical trials in luteal support as part of an ART treatment using dydrogesterone (n=1036) and from spontaneous reporting. Frequencies are based on the most conservative approach. (See Table 2.) Click on icon to see table/diagram/image Undesirable effects in adolescent population: Based on spontaneous reports and limited clinical trial data, the adverse reaction profile in adolescents is expected to be similar to that seen in adults. Undesirable effects that are associated with an estrogen-progestogen treatment (see also Precautions and the product information of the estrogen preparation): Breast cancer, endometrial hyperplasia, endometrial carcinoma, ovarian cancer.

Venous thromboembolism. Myocardial infarction, coronary artery disease, ischemic stroke. In vitro data show that the major metabolic pathway generating the main pharmacologically active metabolite 20α dihydrodydrogesterone (DHD) is catalyzed by aldo-keto reductase 1C (AKR 1C) in human cytosol. Next to the cytosolic metabolism there are metabolic transformations by cytochrome P450 iso-enzymes (CYPs), nearly exclusively via CYP3A4, resulting in several minor metabolites.

The main active metabolite DHD is substrate for metabolic transformation by CYP3A4. Therefore, the metabolism of dydrogesterone and DHD may be increased by concomitant use of substances known to induce CYP enzymes such as anticonvulsants (e.g., phenobarbital, phenytoin, carbamazepine), anti-infectives (e.g., rifampicin, rifabutin, nevirapine, efavirenz) and herbal preparations containing e.g.

St John’s Wort (Hypericum perforatum), sage, or gingko biloba. Ritonavir and nelfinavir, although known as strong cytochrome enzyme inhibitors, by contrast exhibit enzyme-inducing properties when used concomitantly with steroid hormones. Clinically, an increased metabolism of dydrogesterone may lead to a decreased effect.

In vitro studies have shown that dydrogesterone and DHD do not inhibit or induce CYP drug metabolizing enzymes at clinically relevant concentrations. Special precautions for disposal and other handling: Any unused product or waste material should be disposed of in accordance with local requirements.

Incompatibilities: Not applicable. Special precautions for storage: This medicinal product does not require any special storage condition. Do not store above 30°C. Keep the blister in the outer carton, in order to protect from moisture. Shelf-Life: 5 years. G03DB01 – dydrogesterone ; Belongs to the class of pregnadien derivative progestogens used in progestogenic hormone preparations.

FC tab 10 mg x 20’s.
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What happens after taking duphaston?

About Duphaston 10 mg Tablet 10’s – Duphaston 10 mg Tablet 10’s refers to the class of drugs known as steroid hormones. It is also combined with estrogens for hormone replacement therapy in menopausal women and low sex hormone levels in women. Infertility is the inability to conceive within 12 months.

1. On the other hand, Premenstrual syndrome comprises signs and symptoms like mood swings, tender breasts, food cravings, fatigue, irritability, and depression.
2. It occurs during certain days of the menstrual periods in females, generally just before their menses.
3. Duphaston 10 mg Tablet 10’s is a female hormone that controls women’s ovulation and menstruation.

Duphaston 10 mg Tablet 10’s causes secretive changes in the uterus’s endometrium lining, promotes the breast’s development, relaxes the uterus, blocks the maturation and release of the follicle, and retains pregnancy. Your doctor will advise your dose and how often you need to take this medication based on your medical condition.

• While using this medicine, you may sometimes have breast tenderness, swelling in other parts of the body, headaches, migraines, mood swings, depression, acne, tummy (abdominal) pain, back pain, and vaginal bleeding.
• Most of these side effects of Duphaston 10 mg Tablet 10’s do not require medical attention and gradually resolve over time.

However, if the side effects are persistent, reach out to your doctor. Try not to stop taking this medicine of your own. Using Duphaston 10 mg Tablet 10’s may increase the risk of blood clots. Make sure that before taking this medicine, you inform your doctor if you have had breast cancer, unusual bleeding in the vagina, liver disease, or any other health problems.
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Does duphaston delay periods if not pregnant?

Alcohol – Q: Can I consume alcohol with Duphaston tablet? A: Limited information is available on the interaction of Duphaston tablet with alcohol. However, if you are pregnant, consumption of alcohol should be avoided as it may harm the foetus.

Duphaston tablet should be taken as directed by your doctor. Swallow the tablet with a glass of water with or without food. If the patient has to take more than one tablet, they should be spread evenly over the day. For example, one tablet in the morning and one in the evening. The tablet should be taken at the same time each day. This will make sure that there is a constant amount of this medicine in the body. This medicine prescribed for a particular patient shouldn’t be passed on to others. It may harm them, even if their symptoms are the same.

Store Duphaston tablets at temperature not exceeding 25°C Protect from light and moisture Keep it out of the reach of children

Duphaston tablet treats disorders related to the female reproductive cycle, infertility, irregular menses and uterine bleeding. Determine the cause of abnormal uterine bleeding before you begin Duphaston treatment. In the early stages of treatment, the medicine may result in breakthrough bleeding and spotting. Duphaston tablet can be used by pregnant women only when prescribed by the doctor. The tablet should be taken at the same time each day. This will ensure that there is a constant amount of this medicine in the body. You should not take Duphaston and epilepsy medicines like phenobarbital, phenytoin and carbamazepine.

A: Do not self-medicate with the medicine. It may be used Duphaston under medical supervision. A: There are several reasons for miscarriage. If the reason for repeated miscarriages is a deficiency of hormone progesterone, then Duphaston may help. A: No, it is not known to cause constipation.

• If you are pregnant, then you may experience constipation.
• A: Yes, it is safe in pregnancy.
• It was estimated that more than 10 million pregnancies had been exposed to dydrogesterone.
• So far, there were no indications of the harmful effect of dydrogesterone use during pregnancy.
• However, it should be taken under medical supervision only.

A: Yes, it may cause nausea. A: No, the medicine is not meant for stopping periods. A: No, it does not delay periods. You should avoid taking the medicine for other condition which is not prescribed by the doctor. A: Breakthrough bleeding and spotting may sometimes occur during the first months of treatment.

If it happens persistently during or even after treatment has been discontinued, you must inform your doctor immediately. A: Duphaston 10mg side effects include vaginal bleeding, headache, nausea, vomiting, breast tenderness, menstrual disorders, etc. A: You must take Duphaston in the same dose and frequency as advised by your doctor.

Self-medication should always be avoided. A: Duphaston might cause weight gain as it is prescribed as hormonal replacement therapy. Retention of water can cause the individual to gain weight. It occurs due to a condition called ‘estrogen dominance’. A: No clinical evidence is there to show that the individuals’ fertility will decrease after taking the standard dose prescribed.

However, one should always take Duphaston only on the doctor’s advice. A: Yes, Duphaston tablet is a synthetic form of the female hormone progesterone. A: Progesterone is a female hormone crucial for maintaining the appropriate menstrual cycle and functioning of the uterus. When the body produces insufficient progesterone, it may cause infertility, miscarriages, premenstrual syndrome, irregular menses and other disorders related to the disturbed female reproductive cycle.

A: The effect of Duphaston tablet lasts about 5 to 7 days. However, you should always take this medicine exactly as your doctor recommends. Do not stop taking this medicine on your own. A: Duphaston tablet is used for the treatment of pain during menses, absence of menses and irregular cycles.
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Does Duphaston help in conceiving?

In Treatment of Female infertility – Duphaston 10mg Tablet aids in infertility by preparing the womb lining for pregnancy. It also helps in the regulation of the menstrual period and the prevention of repeated miscarriages. Duphaston 10mg Tablet can increase the chances of a successful pregnancy in women who have a history of recurrent abortions.
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Does Duphaston cause pregnancy symptoms?

Is there a way to differentiate between symptoms caused by duphaston and actual pregnancy ? – PCOD/PCOS : trying to conceive Hi All, Its been 2 yrs since I have started trying to have a baby. I am on clomid and duphaston tablets. I have read that duphaston causes side effects like nausea, bloating, breast pain, etc.

Which are the symptoms of pregnancy as well. Last month I went through ovulation monitoring and everything was fine. Due to the pregnancy like symptoms I was super happy and took many pregnancy testes just to get negative. I don’t want to raise my hopes again. Is there a way to differentiate between duphaston effects and actual pregnancy ? Are you sure you want to delete? PCOD/PCOS, or polycystic ovarian syndrome or disorder,can affect many of us.One of the problems is infertility, but its a situation that can be treated.

Whether its using metformin, loosing weight, dietary changes or other fertility medications, there is hope for all the women with PCOD to conceive a healthy baby. Discuss your concerns here and support one another with your experiences. Have a lovely Day.583 posts Created 20/01/12 : Is there a way to differentiate between symptoms caused by duphaston and actual pregnancy ? – PCOD/PCOS : trying to conceive
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When to take pregnancy test

When you can do a pregnancy test – You can carry out most pregnancy tests from the first day of a missed period. If you don’t know when your next period is due, do the test at least 21 days after you last had unprotected sex. Some very sensitive pregnancy tests can be used even before you miss a period.
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How many tablets of Duphaston should I take

Duphaston Dosage/Direction for Use Always take Duphaston exactly as the doctor has prescribed. If there are any questions, contact the doctor or pharmacist. If the patient forgets to take the tablet(s), do not take a double dose to compensate for it. If the patient requires further information, please ask the doctor or pharmacist for advice.

For hormone replacement therapy: In combination with continuous oestrogen therapy, take one tablet daily for 14 consecutive days of a 28 day cycle. In combination with cyclical oestrogen therapy, take one tablet daily during the last 12 to 14 days of oestrogen therapy. For doctors: If endometrial biopsies or ultrasound reveal inadequate progestational response, 20 mg dydrogesterone should be prescribed.

If the patient is not sure what type of oestrogen therapy, talk to the doctor before taking Duphaston. Posology for specific indications: Dysmenorrhoea (painful menstruation): Take one tablet twice daily from day 5 to day 25 of the cycle. Endometriosis (abnormal growth of uterine tissues outside the uterus): Take one tablet two or three times daily from day 5 to day 25 of the cycle or continuously (as prescribed by the doctor).

1. Dysfunctional bleeding (to stop bleeding): Take one tablet twice daily for five to seven days.
2. Dysfunctional bleeding (to prevent bleeding): Take one tablet twice daily from day 11 to day 25 of the cycle.
3. Amenorrhoea (cessation of menstruation): The doctor should prescribe an oestrogen along with Duphaston.

Then take the oestrogen once daily from day 1 to day 25 of the cycle, together with one tablet of dydrogesterone twice daily from day 11 to day 25 of the cycle. Premenstrual syndrome: Take one tablet twice daily from day 11 to day 25 of the cycle. Irregular cycles: Take one tablet twice daily from day 11 to day 25 of the cycle.

1. Threatened abortion: Take four tablets at once, then one tablet every eight hours until symptoms abate.
2. Habitual abortion: Take one tablet twice daily until the twentieth week of pregnancy.
3. Infertility due to luteal (yellow body) insufficiency: Take one tablet daily from day 14 to 25 of the cycle.
4. Continue the treatment for at least six consecutive cycles.

In addition, it is advisable to continue treatment for the first few months of pregnancy as described under “Habitual abortion”. If the patient is uncertain about how long to continue the treatment, talk to the doctor. Luteal support as part of an Assisted Reproductive Technology (ART) treatment: Take one tablet three times daily (30mg daily) starting at the day of oocyte retrieval and continuing for 10 weeks if pregnancy is confirmed.
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Why am I still bleeding after taking Duphaston

Breakthrough bleeding and spotting may sometimes occur during the first months of treatment. If breakthrough bleeding or spotting appears after some time on therapy, or continue after treatment has been discontinued, you must inform your doctor immediately. You should examine your breasts regularly for any changes.
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How long should you lie down to conceive?

4. Lay down and relax for a few minutes after sex – Standing up or going to the bathroom after sex may pull sperm away from their destination. So, lying on your back for 15 minutes or so after sex may help keep sperm moving in the right direction.
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Can I ovulate while on Duphaston?

4. Discussion – This retrospective cross-sectional study revealed that in IVF/ICSI cases, oral prescription of Duphaston can be successfully used as an alternative to GnRH antagonist in patients undergoing controlled ovarian stimulation. Our findings confirmed that an oral delivery of Duphaston is an effective method in producing competent oocytes and blocking premature LH surges.

Duphaston is a congener of progesterone with some but not all of the effects of progesterone, and it is safe without androgenic effects even at a high dose (11). Structural comparison of progesterone and Duphaston shows that Duphaston contains an extra double bond between 6- and 7-carbons. Furthermore, 10-carbon of Duphaston contain methyl group in α position, while methyl group on the 10-carbon of progesterone is located in β position (12, 13).

These differences in the structure enhance the stability and bioavailability of Duphaston which improves its absorption and efficiency (14). This study demonstrated that Duphaston stimulates ovulation in a better manner and causes more oocyte retrieval in comparison with Cetrotide.

1. Furthermore, in the case group who were administered Duphaston, the number of follicles above 14 mm, mature oocyte (MII), and the total number of viable embryos was higher than the control group; however, these differences were not significant.
2. These results indicated that Duphaston was effective on controlled ovarian stimulation without any complications.

These results are in agreement with previous studies (15, 16). With regard to the progesterone level and oocyte/follicles quality, Zavareh and coworker (17) reported that increase of blood progesterone concentration may inhibit development of follicles and oocytes which lead to reduced fertility potential.

Our finding demonstrated that Duphaston at the used dose in this study not only had no adverse effect on the development of follicles and oocytes but also caused more oocyte retrieval in comparison with the GnRH antagonists. These results are in agreement with the study of Hamdi and colleagues (18), who showed that medroxyprogesterone (a form of progesterone) has no adverse effects on oocyte or follicles development.

It should be mentioned that further investigation is required to assess the higher dose of Duphaston or other progesterone congeners on follicles development. Study also revealed that no premature LH surge was observed during COH in patients and it seems Duphaston had suitable effects on the premature LH surge control.

• Additionally, in accordance with this study, Zhu and co-workers (9) reported no premature LH surge in patients who used Duphaston for COH.
• The correlation between progesterone and LH surge is not completely clear.
• During COH, multiple follicles grow along with the dramatically increased estradiol levels, and the coordinated roles of estrogen and progesterone may be more powerful for suppressing LH levels” (3).

Richter and co-authors reported that LH surge takes place following the activation, transmission, and the GnRH surge (8, 19). Progesterone prevents premature LH surge by blocking the GnRH surge induction system (3). In agreement with this, it has shown that progestin administration during the normal follicular phase results in decrease of plasma levels of LH (20).

Studies show that estradiol-induced LH surge-generating signal can be blocked by progesterone in early stages (immediately after estradiol removal) of signal transmission (8, 9, 21). Therefore, the role of progesterone in the LH surge depends on the time of its administration (17). Results indicated that to prevent premature LH surge in IVF cases, Duphaston could be used as an appropriate medication instead of Cetrotide in the patients who underwent controlled ovarian stimulation, because it had no complication in comparison to Cetrotide and is also more effective.

Duphaston might be a good option in clinical practice, since oral administration is more patient-friendly than the injectable form. The choice for either should be based mainly on the availability, cost, and side effects. The lack of pregnancy and neonatal outcomes are the limitations of this study.
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What happens if you don’t start your period after taking progesterone

DIAGRAM 2 – If your period starts while you are still taking pro- gesterone/MPA, always take it for the full 14 days, If this early flow persists, or you are in perimenopause, then you either need daily progesterone /MPA for three months or to increase the dose of cyclic progesterone therapy to 400 mg.

1. The early flow is a sign that your body is making high levels of estrogen that are over-stimulating the endometrium ( uterus lining) and causing heavy bleeding.
2. If you have not started to flow within 2 weeks of taking cyclic progesterone /MPA, it means your own estrogen levels are low.
3. After 14-days “off,” start the next progesterone cycle.

As soon as your flow returns, then start taking progesterone /MPA again, 14 days after the start of your flow, as shown in Diagram 1.
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What happens if you don’t bleed after taking progesterone?

Possible Outcomes of the Test –

If the patient experiences bleeding after the progestin she has estrogen present but is not ovulating (anovulation). If no withdrawal bleeding occurs, either the patient has very low estrogen levels or there is a problem with the outflow tract such as uterine synechiae (adhesions) or cervical stenosis (scarring).

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What happens if progesterone pills does not start period?

What happens if I don’t get my period after using progesterone? – If you have confirmed there is no pregnancy, and you still don’t get your period after using progesterone, your health care provider will do further testing to determine what’s going on.
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Does progesterone make you not have a period

pronounced as (proe jes’ ter one) Progesterone is used as a part of hormone replacement therapy in women who have passed menopause (the change of life) and have not had a hysterectomy (surgery to remove the uterus). Hormone replacement therapy usually includes estrogen, which is used to treat symptoms of menopause and reduce the risk of developing certain diseases.

However, estrogen can also cause abnormal thickening of the lining of the uterus and increase the risk of developing uterine cancer. Progesterone helps to prevent this thickening and decreases the risk of developing uterine cancer. Progesterone is also used to bring on menstruation (period) in women of childbearing age who have had normal periods and then stopped menstruating.

Progesterone is in a class of medications called progestins (female hormones). It works as part of hormone replacement therapy by decreasing the amount of estrogen in the uterus. It works to bring on menstruation by replacing the natural progesterone that some women are missing.

Progesterone comes as a capsule to take by mouth. It is usually taken once a day in the evening or at bedtime. You will probably take progesterone on a rotating schedule that alternates 10 to 12 days when you take progesterone with 16 to 18 days when you do not take the medication. Your doctor will tell you exactly when to take progesterone.

To help you remember to take progesterone, take it around the same time in the evening. Follow the directions on your prescription label carefully, and ask your doctor or pharmacist to explain any part you do not understand. Take progesterone exactly as directed.
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